FOOD MATERIAL FOR INHIBITING OSTEOCLASTOGENESIS

摘要

Disclosed is an agent for inhibiting the formation of an osteoclast, which comprises a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption, and which is useful for the prevention or treatment of a bone disease: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction that contains a protein having a molecular weight of 80,000 to 85,000 Daltons; (3) in the constituent amino acid composition of the milk protein fraction, the basic amino acid content is 16 to 18 wt%, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) [basic amino acid(s)/acidic amino acid(s)] is 0.65 to 0.85; and (4) the milk protein fraction has an activity of inhibiting the formation of an osteoclast.