| 摘要 |
<p>Systems and methods are disclosed herein for applying near-infrared optical enegies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (??-steady) of all irradiated cells through an optical depolarization effect, This depolarization causes a concomitant decrease in the absolute valie of the trans-membrane potentials ?? of the irradiated mitochondrial and palsma membranes. Many cellular anabolic reactions and drug-reistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ??, the affiliated weakening of the proton motive force ?p, and the associated lowered phosphorylation potential ?Gp. Within the area of irridation exposure, the derease in membrane potentials ?? will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the abitlity to petentiate antimicrobial, antifungal and/or antineoplastic drugs agains only targeted undesirable cells.</p> |
