发明名称 |
Lipid-modified double-stranded RNA having potent RNA interference effect |
摘要 |
<p>An object of the present invention is to provide a novel double-stranded RNA that has high nuclease resistance and high cellular uptake efficiency, and that is capable of producing an excellent RNA interference effect. The present invention provides a lipid-modified double-stranded RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of inhibiting the expression of the target gene, the sense strand having a lipid linked to at least one of the first to sixth nucleotides from the 5′end side directly or via a linker.</p> |
申请公布号 |
AU2008314860(A1) |
申请公布日期 |
2009.04.30 |
申请号 |
AU20080314860 |
申请日期 |
2008.10.24 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY;OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
TAKANORI KUBO;HIROTAKE HAYASHI;HIDEKI OHBA;HIDEKAZU TOYOBUKU |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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