Factor VII or VIIa Gla domain variants

摘要

Disclosed is a Factor VII (FVII) or Factor VIla (FVlla) polypeptide variant having an amino acid sequence that differs in 1-15 amino acid residues relative to the amino acid sequence of human Factor VII (hFVII) or human Factor VIla (hFVIIa) shown in SEQ ID NO: l, wherein a negatively charged amino acid residue has been introduced by substitution in position 36 in the variant sequence.