ANTIBODY DIRECTED AGAINST PRO-GASTRIN RELEASING PEPTIDE, AND USE THEREOF

摘要

Disclosed is a novel high-sensitive ProGRP determination method, which is free from problems such as the fluctuations in measurement values and the operational constraints (e.g., the constraints on the handling of a sample). Specifically disclosed is a method for the determination of a pro-gastrin-releasing peptide and/or a digest thereof using at least two different antibodies each of which can recognize an epitope represented by the amino acid sequence lying between amino acid residue-47 to amino acid residue-68 inclusive in the amino acid sequence depicted in SEQ ID NO:1. The method can detect a ProGRP or a digest thereof in a refrigerated sample within a shorter period, by using the sample in a smaller quantity, and with a higher degree of detection sensitivity, compared with the conventional methods.