PROCESS FOR PRODUCTION OF DISULFONIC ACID COMPOUND, ASYMMETRIC MANNICH CATALYST, PROCESS FOR PRODUCTION OF ß-AMINOCARBONYL DERIVATIVE, AND NOVEL DISULFONATE SALT

摘要

Hexamethylphosphoramide (HMPA) is added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The reaction vessel is purged with oxygen, and is stirred at 80°C for 5 days under 7 atmospheres of oxygen. The reaction solution is cooled to room temperature and subsequently purified, thereby producing potassium (R)-1,1'-binaphthyl-2,2'-disulfonate. (R)-1,1'-Binaphthyl-2,2'-disulfonic acid produced from the disulfonate salt and 2,6-diphenylpyridine are stirred together in acetonitrile, and the solvent is distilled away from the reaction solution under reduced pressure. Subsequently, magnesium sulfate and distilled CH2Cl2 are added to the reaction product, and the resulting mixture is stirred at room temperature for 30 minutes. The solution is cooled to 0°C, and benzaldehydimine in which nitrogen is protected with Cbz and acethylacetone are added thereto dropwise over 1 hour. The resulting mixture is further stirred at 0°C for 30 minutes. In this manner, a corresponding ß-aminocarbonyl derivative can be produced in an yield of 91% and at a rate of enantiomeric excess of 90% ee.