BACULOVIRAL VECTORS COMPRISING REPEATED CODING SEQUENCES WITH DIFFERENTIAL CODON BIASES
摘要
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.
申请公布号
WO2009014445(A3)
申请公布日期
2009.04.30
申请号
WO2008NL50512
申请日期
2008.07.25
申请人
AMSTERDAM MOLECULAR THERAPEUTICS B.V.;BAKKER, ANDREW, CHRISTIAN;HERMENS, WILHELMUS, THEODORUS, JOHANNES
发明人
BAKKER, ANDREW, CHRISTIAN;HERMENS, WILHELMUS, THEODORUS, JOHANNES