摘要 |
The invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer. |
申请人 |
PFIZER INC.;CANCER RESEARCH TECHNOLOGY LTD. |
发明人 |
STEINFELDT, HEIDI MARIE;CALVERT, ALAN HILARY;DEWJI, MOHAMED RAZA;JONES, CHRISTOPHER;KLAMERUS, KAREN J.;PLUMMER, ELIZABETH RUTH;STRATFORD, IAN J.;WILLIAMS, KAYE JANINE;BORITZKI, THEODORE JAMES;CURTIN, NICOLA JANE;HOSTOMSKY, ZDENEK;KAUFMAN, RHONDA;NEWELL, DAVID RICHARD;REICH, STEVEN DAVID;THOMAS, HUW DAVID |