发明名称 |
Process for producing 5-(2'-pyridyl)-2-pyridone derivative |
摘要 |
The present invention provides a method of industrially and advantageously producing a 5-(2'-pyridyl)-2-pyridone derivative. The present invention relates to a production method of a 5-(2'-pyridyl)-2-pyridone derivative represented by the formula (VI), which includes reacting a pyridine derivative of the formula (I) with a brominating agent to give a 5-bromopyridine derivative of the formula (II), reacting the obtained 5-bromopyridine derivative with a metallizing agent to give an organometallic compound of the formula (III), reacting the obtained organometallic compound with a 2-sulfonylpyridine derivative of the formula (IV) to give a 6-alkoxy-3,2'-bipyridine derivative of the formula (V) and hydrolyzing the obtained 6-alkoxy-3,2'-bipyridine derivative: wherein each symbol is as defined in the Description.
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申请公布号 |
US7524967(B2) |
申请公布日期 |
2009.04.28 |
申请号 |
US20050521800 |
申请日期 |
2005.08.02 |
申请人 |
KURARAY CO., LTD.;EISAI R & D MANAGEMENT CO., LTD. |
发明人 |
KOYAKUMARU KENICHI;FUKUNAGA YOSHIMI;SATAKE YOUICHI |
分类号 |
C07D401/04;C07D213/64;C07D213/69 |
主分类号 |
C07D401/04 |
代理机构 |
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主权项 |
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地址 |
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