发明名称 |
Insertion of furin protease cleavage sites in membrane proteins and uses thereof |
摘要 |
Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be used to produce virus membrane protein domains for structural analysis and for trials as vaccines.
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申请公布号 |
US7521209(B2) |
申请公布日期 |
2009.04.21 |
申请号 |
US20070677387 |
申请日期 |
2007.02.21 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
BROWN DENNIS T. |
分类号 |
C12Q1/70;C12N5/06;C12N5/16;C12P21/06 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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