发明名称 |
Use of targeted cross-linked nanoparticles for in vivo gene delivery |
摘要 |
The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
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申请公布号 |
US7514098(B2) |
申请公布日期 |
2009.04.07 |
申请号 |
US20020159241 |
申请日期 |
2002.05.30 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BEDNARSKI MARK D.;GUCCIONE SAMIRA;LI KING CHUEN |
分类号 |
A61K9/127;C12N15/09;A01N43/04;A61K31/353;A61K31/538;A61K31/70;A61K31/7088;A61K38/00;A61K47/18;A61K47/24;A61K47/28;A61K47/32;A61K47/34;A61K47/48;A61K48/00;A61K51/12;A61P9/00;A61P27/00;A61P35/00;C07D239/14;C07H21/00;C12N15/00;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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