IDENTIFICATION OF CONTACTINS AND L1- CAMS AS LIGANDS FOR THE AMYLOID PRECURSOR PROTEIN

摘要

The invention relates to APP regulation by extracellular binding partners. More specifically, the invention porvides methods and compositions for treating or preventing diseases, such as Alzheimer's disease, mediated by Contactins and/or Ll family of proteins. The invention further provides methods for identifying molecules that modulate the binding and/or processing of APP and other related molecules.