发明名称 |
3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
摘要 |
A method is described wherein prostate or breast cancer is detected by quantifying a 3.4-kilobase deletion in the mitochondrial DNA (mtDNA) of a test sample. The deletion is located between nucleotides 10744-14124 of the mitochondrial genome. An increase in the amount of the deletion relative to the amount of the deletion in non-cancerous prostate and breast tissue is indicative of prostate and breast cancer, respectively. The deletion is detected by detecting the sublimon, i.e. the re-circularized deleted fragment that corresponds to SEQ ID NO:1. |
申请公布号 |
AU2007359381(A1) |
申请公布日期 |
2009.04.02 |
申请号 |
AU20070359381 |
申请日期 |
2007.09.26 |
申请人 |
GENESIS GENOMICS INC. |
发明人 |
ANDREA MAGGRAH;RYAN PARR;ROBERT THAYER;KERRY ROBINSON;JENNIFER CREED;GABRIEL DAKUBO;BRIAN REGULY |
分类号 |
C12Q1/68;C07H21/00;C12N15/00;C12N15/10;C12N15/11;C12N15/12;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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