ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
摘要
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
申请公布号
WO2009042962(A2)
申请公布日期
2009.04.02
申请号
WO2008US78014
申请日期
2008.09.26
申请人
PORTOLA PHARMACEUTICALS, INC.;LU, GENMIN;PHILLIPS, DAVID R.;ANDRE, PATRICK;SINHA, UMA
发明人
LU, GENMIN;PHILLIPS, DAVID R.;ANDRE, PATRICK;SINHA, UMA