TRIAZOLE-BASED AMINOGLYCOSIDE-PEPTIDE CONJUGATES AND METHODS OF USE
摘要
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycoside antibiotic may exhibit antimicrobial activities against Gram-positive and/or Gram-negative strains and display significantly enhanced activity against multi-drug resistant MRSA and MRSE when compared to their unconjugated aminoglycoside antibiotic counterparts.
申请公布号
WO2009037592(A2)
申请公布日期
2009.03.26
申请号
WO2008IB03486
申请日期
2008.05.28
申请人
UNIVERSITY OF MANITOBA;SCHWEIZER, FRANK;ZHANEL, GEORGE, G.;BERA, SMRITILEKHA