<p>A security protection box is provided, which is applied to the protection filed of electronic circuit. The security protection box is used to compass the protected region of a protected circuit board in order to protect the elements in the protected region. The security protection box comprises a circuit board, the circuit board with thin center and heavy periphery forms box shape, and the circuit board has the circuit routing layers, the circuit routing layers trigger the interlock circuit to erase or destroy the information in the elements in the protected region when the circuit routing layers are physical attacked. The present invention protects the elements in the protected region through setting the circuit board with thin center and heavy periphery on the protected circuit board.</p>
