The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering an effective amount of a compound of formula I to the person or animal.
申请公布号
WO2009009793(A3)
申请公布日期
2009.03.26
申请号
WO2008US69974
申请日期
2008.07.14
申请人
UNIVERSITY OF SOUTH FLORIDA;CHENG, JIN, Q.;SUN, MEI;SEBTI, SAID, M.