COUMARIN DERIVATIVES, PREPARATION PROCESSES AND USES THEREOF

摘要

Coumarin derivatives represented by general formula (I), their preparation methods, and their uses as angiogenesis inhibitors for the treatment of tumor and angio-retina diseases. This type of compounds is obtained by modification based on the structure of osthol. Vascular endothelial cell growth inhibiting experiments show that compounds of formula (I) have obvious EVC-304 cell multiplication inhibiting activity. Compared with combretastatin A-4 (CA4), the inhibiting activity of formula (I) is stronger and 1.5-4.0 times the activity of CA4.