发明名称 |
HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11?-HYDROXYSTEROID DEHYDROGENASE |
摘要 |
<p>Disclosed is a compound useful as a type-I 11ß-hydroxysteroid dehydrogenase inhibitor. Specifically disclosed is a compound represented by the formula shown below, a pharmaceutically acceptable salt thereof, or a solvate of the compound or the pharmaceutically acceptable salt, wherein X represents O or S; and the broken line and the wavy lines independently represent the presence or absence of a bond, provided that: (i) when the broken line represents the presence of a bond, then the wavy lines independently represent the absence of a bond and R2 and R3 independently represent a hydrogen, a halogen or the like; and (ii) when the broken line represents the absence of a bond, then the wavy lines independently represent the presence of a bond, R1 and R4 independently represent a hydrogen, a halogen or the like, R2 and R3 independently represent a hydrogen, a halogen or the like, and R5 and R6 independently represent a hydrogen, an alkyl which may be substituted or the like.</p> |
申请公布号 |
WO2009038064(A1) |
申请公布日期 |
2009.03.26 |
申请号 |
WO2008JP66708 |
申请日期 |
2008.09.17 |
申请人 |
INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.;SHIONOGI & CO., LTD.;ITAI, AKIKO;MUTO, SUSUMU;TOKUYAMA, RYUKO;FUKASAWA, HIROSHI;YANASE, TAKESHI |
发明人 |
ITAI, AKIKO;MUTO, SUSUMU;TOKUYAMA, RYUKO;FUKASAWA, HIROSHI;YANASE, TAKESHI |
分类号 |
C07D265/24;A61K31/536;A61K31/54;A61K31/5415;A61K31/547;A61K31/55;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P43/00;C07D279/06;C07D279/08;C07D417/04;C07D417/12 |
主分类号 |
C07D265/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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