发明名称 |
BIO-DEGRADABLE/ABSORBABLE POLYMER HAVING REDUCED METAL CATALYST CONTENT, AND PROCESS FOR PRODUCTION THEREOF |
摘要 |
The present invention provides a safe biodegradable and bioabsorbable polymer having an extremely low metal catalyst content, while retaining the properties desired for a medical implant or the like; and a process for producing the same. The present invention further provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and µ-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25/75 to 45/55 at less than 40°C, and drying the copolymer. 13. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and µ-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 45/55 to 55/45 at less than 40°C, and drying the copolymer. |
申请公布号 |
EP2039714(A1) |
申请公布日期 |
2009.03.25 |
申请号 |
EP20070745462 |
申请日期 |
2007.06.18 |
申请人 |
GUNZE LIMITED |
发明人 |
ARIMURA, HIDETOSHI;TAKAHASHI, YOSHITAKE;YAMAUCHI, KOJI |
分类号 |
A61L17/12;A61L27/18;A61L27/58;A61L31/14;C08G63/08;C08G63/82;C08G63/90 |
主分类号 |
A61L17/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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