发明名称 |
LO-CD2A ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION |
摘要 |
The present invention relates to a LO-CD2a antibody and methods of using suc h antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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申请公布号 |
CA2262546(C) |
申请公布日期 |
2009.03.17 |
申请号 |
CA19962262546 |
申请日期 |
1996.08.16 |
申请人 |
BIOTRANSPLANT, INC.;UNIVERSITE CATHOLIQUE DE LOUVAIN |
发明人 |
POSTEMA, CHRISTINA E.;LATINNE, DOMINIQUE;BAZIN, HERVE;KAPLAN, RUTH;WHITE-SCHARF, MARY E.;KIEBER-EMMONS, THOMAS |
分类号 |
C07K16/46;C12N15/09;A61K38/00;A61K39/395;A61P37/06;A61P43/00;C07K16/18;C07K16/28;C07K19/00;C12P21/08 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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