SCREENING METHOD OF SIGNAL TRANSMISSION REGULATING AGENT

摘要

PROBLEM TO BE SOLVED: To provide a screening method of a signal transmission regulating agent capable of regulating the activation of a signal transmission route through erbB1. SOLUTION: In the screening method of the signal transmission regulating agent, erbB1 or its partial peptide and FRS2βor its partial peptide are brought into contact with each other in the presence of a candidate substance to detect to the acceleration or suppression of the interaction of both of them by the candidate substance, and to select the candidate substance accelerating the interaction as a regulating agent for accelerating signal transmission, so that the candidate substance suppressing the interaction is selected as a regulating agent for suppressing the signal transmission. The partial peptide of erbB1 is peptide containing a tyrosine kinase domain and the partial peptide of FRS2βis peptide containing a PTB domain. A substance for regulating the activation of the signal transmission through erbB can be screened by this method. The obtained substance is used together with FRS2βto be used in the inhibition of signal transmission or the prevention or treatment of cancer. COPYRIGHT: (C)2009,JPO&INPIT