发明名称 |
C-C chemokine receptor 3 proteins |
摘要 |
The present invention relates to methods of inhibiting a mammalian C-C chemokine receptor 3 protein (CCR3). The invention further relates to methods of treating an inflammatory disease or condition. Administration of a compound which inhibits or promotes CCR3 function to an individual in need of therapy provides a new approach to selective modulation of leukocyte function, which is useful in a variety of inflammatory and autoimmune diseases, or in the treatment of infections. As a major leukocyte chemokine receptor present in leukocytes such as eosinophils and lymphocytes, the receptor provides a key target for drug screening and design.
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申请公布号 |
US2009068188(A1) |
申请公布日期 |
2009.03.12 |
申请号 |
US20080218102 |
申请日期 |
2008.07.11 |
申请人 |
GERARD CRAIG J;GERARD NORMA P;MACKAV CHARLES R;PONATH PAUL D;POST THEODORE W;QIN SHIXIN |
发明人 |
GERARD CRAIG J.;GERARD NORMA P.;MACKAV CHARLES R.;PONATH PAUL D.;POST THEODORE W.;QIN SHIXIN |
分类号 |
A61K39/395;C12P21/08;A61K38/00;A61K47/48;A61P11/06;A61P29/00;A61P35/00;A61P37/06;A61P37/08;C07K14/715;C07K16/18;C07K16/28;C12N5/10;C12N15/00;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;C12R1/91;G01N33/566;G01N33/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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