发明名称 IMPROVEMENTS IN OR RELATING TO COMPOSITIONS FOR THE TREATMENT OR PROPHYLAXIS OF VIRAL INFECTIONS
摘要 <p>A compound of the general formula (III): wherein X is O, S, NH or CH2; Y is O, S or NH; Z is O, S or CH2; R1 is C1-8 alkyl, especially C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl; at least one of R2 and R3 is H-[R4-R5]n-R6-, in which: H-[R4-R5]n- comprises an oligopeptide, R4 being an amino acid and R5 being an amino acid selected from proline, alanine, hydroxyproline, dihydroxyproline, thiazolidinecarboxylic acid (thioproline), dehydroproline, pipecolic acid (L-homoproline), azetidinecarboxylic acid, aziridinecarboxylic acid, glycine, serine, valine, leucine, isoleucine and threonine, R6 is a neutral, non-polar amino acid moiety that is bonded to R5 by a peptide bond, and n is 1, 2, 3, 4 or 5; and the other of R3 and R2 is H-[R4-R5]n-R6- or H; or a pharmaceutically acceptable salt thereof.</p>
申请公布号 WO2009030410(A1) 申请公布日期 2009.03.12
申请号 WO2008EP07009 申请日期 2008.08.27
申请人 KATHOLIEKE UNIVERSITEIT LEUVEN;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;BALZARINI, JAN;CAMARASA, MARIA JOSE;VELAZQUEZ, SONSOLES 发明人 BALZARINI, JAN;CAMARASA, MARIA JOSE;VELAZQUEZ, SONSOLES
分类号 C07K5/02;A61K31/198;A61K31/7068;C07H19/24;C07K7/02 主分类号 C07K5/02
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