This invention is directed to methods for determining if a test compound can ameliorate tau protein induced reduction of long term potentiation in a neural structure. The invention is also directed to methods for determining if a test compound can re-establish or rescue synaptic function in a neural structure following damage by tau proteins. Also encompassed by disclosures in this invention are methods to determine if a test compound can increase synaptic function in a neural structure contacted with tau proteins and methods for determining if a test compound is capable of treating Alzheimer's disease or other tauopathies in a subject.
申请公布号
WO2009033151(A1)
申请公布日期
2009.03.12
申请号
WO2008US75584
申请日期
2008.09.08
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;ARANCIO, OTTAVIO;PUZZO, DANIELA;MOE, JAMES, G.