METHOD FOR PREPARING (R)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE AND SALTS THEREOF

摘要

A manufacturing method of (R)-1-[(4-chlorophenyl) phenylmethyl piperazine] is provided to have high yield and high optical purity, to be conveniently manufactured and to be usefully used as intermediate. A manufacturing method of (R)-1-[(4-chlorophenyl) phenylmethyl piperazine] indicated as a chemical formula 1 or salts thereof comprises steps of: manufacturing a compound of a chemical formula 4 by reacting (R)-(4-chlorophenyl) phenylmethyl amine indicated as a chemical formula 2 with a compound of a chemical formula 3 under presence of organic base; and hydrolyzing the manufactured compound of the chemical formula 4 using strong acid or strong base. In the chemical formula 3 and the chemical formula 4: R is hydrogen, C1-4 alkyl, C1-4 alkoxy, C3-10 aryl, C3-10 aryloxy or benzyloxy; X is halogen, methanesulfonyl or p-toluenesulfonyl.