发明名称 |
6-(HETEROCYCLE-SUBSTITUTED BENZYL)-4-OXOQUINOLINE COMPOUND AND USE OF THE SAME AS HIV INTEGRASE INHIBITOR |
摘要 |
<p>The present invention relates to a compound represented by the following formula [I]
wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV agent and an HIV integrase inhibitor containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an anti-HIV agent, or as an agent for the prophylaxis or treatment of AIDS. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agnet. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.</p> |
申请公布号 |
EP2033954(A1) |
申请公布日期 |
2009.03.11 |
申请号 |
EP20070845259 |
申请日期 |
2007.06.22 |
申请人 |
JAPAN TOBACCO, INC. |
发明人 |
SATOH, MOTOHIDE;ARAMAKI, HISATERU;YAMASHITA, MASAKI;INOUE, MASAFUMI;KAWAKAMI, HIROSHI;SHINKAI, HISASHI;NAKAMURA, HIROSHI;MATSUZAKI, YUJI;WAMAKI, SHUICHI |
分类号 |
C07D215/56;A61K31/4709;A61K31/496;A61K31/5377;A61K31/541;A61P31/18;A61P43/00;C07D401/10;C07D413/10;C07D417/10 |
主分类号 |
C07D215/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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