发明名称 COMBINATION OF FCGAMMARIIB ANTIBODIES AND CD20-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
摘要 <p>The present invention relates to methods of treatment, prevention, management or amelioration of one or more symptoms of diseases or disorders associated with CD20 expression that encompass administration of a combination of: (A) one or more antibodies that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies bind FcγRIIA, and (B) one or more antibodies that specifically bind to CD20. Such methods include methods of treating, preventing, managing or ameliorating one or more symptoms of a B cell related disease or disorder or an inflammatory disorder. The invention also provides pharmaceutical compositions comprising an anti-FcγRIIB antibody and an anti-CD20 antibody.</p>
申请公布号 EP2032159(A2) 申请公布日期 2009.03.11
申请号 EP20070799049 申请日期 2007.06.26
申请人 MACROGENICS, INC. 发明人 TUAILLON, NADINE;RANKIN, CHRISTOPHER
分类号 A61K39/00;A61P35/00;C07K16/28;G01N33/574 主分类号 A61K39/00
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