| 摘要 |
A tetrapyrollic photosensitizer compound having at least one pendant -CH2CH2CON(CH2CON(CH2COOH)2)2 or -N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a phamaceutically acceptable derivative thereof, wherein R1-R8 and R10 are various substituents and R9 is substituted or unsubstituted -CH2CH2CON(CH2CON(CH2COOH)2)2; or -N(CH2COOH)2. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.
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