| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention claims compound of formula (I) , where X is O or S; R1 is C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkylmethyl, any of which can be optionally substituted by one or more methal groups or halogen atoms, or R1 is 4-(diethylamino)sulfonylphenyl, 2,6-difluorophenyl, 4-methoxyphenyl, 4-cyanomethyl, 3-difluoromethylthiopnehyl, 5-chloro-4-methoxy-thiophene-3-yl, 2-isopropyl-1,3-thiazol-4-yl, quinoline-2-yl, 5-trifluoromethyl-furan-2-yl, 5-methylsulfonyl-thiophene-2-yl, 5-methylthio-thiophene-2-yl, or 5-ethylisoxazene-2-yl; R2 is hydrogen, methyl which can be either in alpha- or beta-configuration; R3 and R4 are the same or different, each is independently hydrogen, halogen, and is simple or double link; or its pharmaceutically acceptable salt or solvate. ^ EFFECT: obtaining compound with glycocorticosteroid effect. ^ 20 cl, 25 ex
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