Transgen mus til screening og til studier af farmakodynamikken og famakokinetikken af ligander, der virker på intracellulære receptorer, og fremgangsmåde til fremstilling deraf

摘要

The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.