LIPOSOME COATED WITH PROTEIN TO PROLONG CIRCULATION TIME IN BLOODSTREAM AND PREPARATION METHOD THEREOF

摘要

A liposome coated with protein is provided to improve the in vivo circulation time in bloodstream compared to the conventional liposome, strengthen the stability in plasma, and inhibit adsorption to plasma protein, thereby enhancing drug delivery efficiency to the target area in the body and continuance of medicine effect exhibition. The liposome coated with protein having increased in vivo circulation time in bloodstream is prepared by binding the protein to the surface of liposome including cationic lipid through ionic bond, wherein the protein is selected from albumin, globulin, glutenin, prolamine, albuminoid, nucleoprotein, glycoprotein, phosphoprotein, lipoprotein, chromoprotein, gelatin, proteose, peptone, dipeptide and tripeptide, and has the average molecular weight of 2,000-1,500,000 Da.