| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for assessing dihydropyrimidine dehydrogenase (DPD) expression levels in tissues, and to prognosticate the highly probable resistance of a patient's tumor to treatment with 5-FU-based therapies by examination of the amount of DPD mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level. <P>SOLUTION: More specifically, oligonucleotide primer pairs, DPD3A and DPD3B, and methods comprising their use for detecting levels of dihydropyrimidine dehydrogenase (DPD) mRNA, are provided. <P>COPYRIGHT: (C)2009,JPO&INPIT |
