GLUCAGON FORMULATIONS

摘要

Glucagon formulations comprising a low viscosity mixture of: i) at least one diacylglycerol; ii) at least one phospholipid; iii) at least one glucagon; iv) at least one biocompatible organic solvent; v) optionally at least one lipid soluble acid; and vi) optionally at least one antioxidant, wherein the pre-formulation generates at least one bulk non-lamellar phase structure upon exposure to excess aqueous fluid are useful in preventing hypoglycemia, particularly in diabetic subjects receiving insulin therapy, and to pre-filled administration devices and kits containing the formulations.