发明名称 |
System and method for adaptive reagent control in nucleic acid sequencing |
摘要 |
An embodiment of a method for adaptive reagent control is described that comprising a) introducing a first concentration of an enzyme reagent into a reaction environment with a reaction substrate, where the enzyme reagent and reaction substrate are constituent parts of a sequencing process; b) measuring a level of activity of the first concentration of the enzyme reagent in the reaction environment, where the level of activity comprises a measurable product of a reaction between the enzyme reagent and the reaction substrate; c) identifying an optimal concentration using the measured level of activity of the first concentration; and d) performing the sequencing process in the reaction environment using the optimal concentration of the enzyme reagent, where the sequencing process comprises an iterative series of sequencing reactions.
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申请公布号 |
US2009053724(A1) |
申请公布日期 |
2009.02.26 |
申请号 |
US20080215455 |
申请日期 |
2008.06.27 |
申请人 |
454 LIFE SCIENCES CORPORATION |
发明人 |
ROTH GEORGE THOMAS;NOBILE JOHN RICHARD;SRINIVASAN MAITHREYAN;CHEN ZHOUTAO;NEALIS JAMES MATTHEW;GOMES XAVIER VICTOR |
分类号 |
C12Q1/68;C12M1/34;C12M1/36;C12Q1/00;C12Q1/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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