Methods for determining the effect of a treatment on the cross-B structure content of a protein; selection of treatments and uses thereof

摘要

The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-beta structure conformation. The invention provides a method for determining a difference in the cross-beta structure content of a protein in a reference sample compared to said protein in a test sample wherein the test sample has been subjected to a treatment that is expected to have an effect on the cross-beta structure content of said protein comprising-determining in said reference sample the cross-beta structure content of said protein-subjecting said protein to a treatment that is expected to have an effect on the cross-beta structure content to obtain said test sample-determining in said obtained test sample the cross-beta structure content of said protein-determining whether the cross-beta structure content of the reference sample is different from the cross-beta structure content in the test sample.