COMBINATION TREATMENT FOR METABOLIC DISORDERS.

摘要

Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis can be treated with a compound selected from an incretin mimetic and a dipeptidyl peptidase IV inhibitor in combination with a Compound of Formula,I or a pharmaceutically acceptable salt thereof, Formula (I) Three of R^1, R², R³, R⁴ and R⁵ are hydrogen and the remainder are independently selected from the group consisting of hydrogen, halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; and m is 0, 2 or 4. R⁶ is hydrogen, O or hydroxy, and X is -OR⁷, wherein R⁷ is hydrogen or alkyl having from 1 to 3 carbon atoms; or R⁶ is hydrogen, and X is -NR⁸R⁹, wherein R⁸ is hydrogen or hydroxy and R⁹ is hydrogen, methyl or ethyl. When X is -NR⁸R⁹, hydroxy none of R¹, R², R³, R⁴ and R⁵ is hydroxy.