| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention concerns new compounds of formula I or their pharmaceutically acceptable salts: , where R1 is selected out of C3-10cycloalkyl-C1-6alkyl, tetrahydropyranyl-C1-6alkyl and tetrahydropyranyl, where the C3-10cycloalkyl-C1-6alkyl, tetrahydropyranyl -C1-6alkyl and tetrahydropyranyl used in definition of R1 are possibly substituted by one or more group selected out of halogen, methyl and ethyl; R2 is C1-10alkyl, where the C1-10alkyl used in definition of R2 is optionally substituted by one or more group selected out of methyl, ethyl; R3 is selected out of -H, C1-10alkyl, C2-10alkenyl, pyrrolidinyl, morpholinyl, piperidinyl, pyrrolidinyl-ethyl, morpholinyl-ethyl, piperidinyl-ethyl and , possibly substituted by one or more group selected out of C1-6alkyl, amino, C1-6alkoxy; or R3 is 2-aminoethoxy-ethyl or (2-hydroxyethyl)amino-ethyl; each of R8 and R9 is C1-10alkyl; and R4 is selected out of -H and C1-10alkyl. Invention also concerns compounds selected out of the group, application of compounds for any of claim points 1-5, pharmaceutical composition, and method of obtaining compounds of the formula I. ^ EFFECT: obtaining new bioactive compounds with agonistic effect selective in respect of CB1 receptors. ^ 11 cl, 12 ex
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