发明名称 |
NEAR INFRARED CHEMILUMINESCENT ACRIDINIUM COMPOUNDS AND USES THEREOF |
摘要 |
<p>A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner conjugated to an acridinium compound, wherein the acridinium compound comprises an acridinium nucleus having an electron-donating substituent directly attached to the acridinium nucleus at the C<SUB>2 </SUB>position. Chemiluminescent acridinium compounds useful in the method have emission maxima close to or in the near infrared (NIR) region (>590 nm). These chemiluminescent acridinium compounds when used in conjunction with short wavelength-emitting acridinium esters (with emission maxima below 450 nm) can be highly useful labels for the simultaneous detection of multiple target analytes in a single assay.</p> |
申请公布号 |
EP1104405(B1) |
申请公布日期 |
2009.02.18 |
申请号 |
EP19990941005 |
申请日期 |
1999.08.10 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS INC. |
发明人 |
NATRAJAN, ANAND;JIANG, QINGPING;SHARPE, DAVID;LAW, SAY-JONG |
分类号 |
C07D219/04;C07D401/12;C07K14/765;C07K16/26;C09K3/00;C09K11/07;C12N15/09;C12Q1/68;G01N21/76;G01N33/532;G01N33/533;G01N33/58 |
主分类号 |
C07D219/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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