发明名称 |
METHODS AND COMPOSITIONS RELATING TO VIRAL FUSION PROTEINS |
摘要 |
Provided herein are isolated paramyxovirus pre-triggered fusion proteins, or functional fragments thereof, which contain one or more CRAC domains in a location that is away from the transmembrane domain. Also provided herein is a computer model of the structure of the pre-triggered F protein. Compositions that directly or indirectly bind and interfere with the normal activity or binding of the pre-triggered F proteins, or the CRAC domains, are useful as antiviral agents in the treatment of paramyxovirus infections. Thus, disclosed herein are methods of screening for antiviral agents, using the isolated pre-triggered F protein, or functional fragments thereof. |
申请公布号 |
WO2008154456(A3) |
申请公布日期 |
2009.02.12 |
申请号 |
WO2008US66223 |
申请日期 |
2008.06.06 |
申请人 |
NATIONWIDE CHILDREN'S HOSPITAL, INC.;PEEPLES, MARK, E.;KENNEDY, MATTHEW;RAY, WILLIAM |
发明人 |
PEEPLES, MARK, E.;KENNEDY, MATTHEW;RAY, WILLIAM |
分类号 |
C07K14/135;G01N33/53 |
主分类号 |
C07K14/135 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|