TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM
摘要
A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature o at least 40°C for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.
申请公布号
WO2009019133(A1)
申请公布日期
2009.02.12
申请号
WO2008EP59640
申请日期
2008.07.23
申请人
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.;MARCHETTI, MARCELLO;IACOANGELI, TOMMASO;CIOTTOLI, GIOVANNI BATTISTA;BIONDI, GIUSEPPE
发明人
MARCHETTI, MARCELLO;IACOANGELI, TOMMASO;CIOTTOLI, GIOVANNI BATTISTA;BIONDI, GIUSEPPE