3'-ETHYNYLCYTIDINE DERIVATIVE.

摘要

Disclosed is a compound which has excellent anti-tumor activity and excellent oral absorbability and is useful as an anti-tumor agent. Specifically disclosed is a 3'-ethynylcytidine derivative represented by the general formula (1) [wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by the formula: (R¹)(R²)(R³)Si- and the other represents a group represented by the formula: (R⁴)(R⁵)(R⁶)Si-; and R¹, R², R³, R⁴, R⁵ and R⁶ independently represent a (substituted) alkyl group, a (substituted) cyclic alkyl group or a (substituted) aryl group] or a salt thereof.