发明名称 |
GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS. |
摘要 |
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. |
申请公布号 |
MX2008015530(A) |
申请公布日期 |
2009.02.06 |
申请号 |
MX20080015530 |
申请日期 |
2007.06.07 |
申请人 |
GENZYME CORPORATION. |
发明人 |
DODGE, JAMES;SHIHABUDDIN, LAMYA;O'RIORDAN, CATHERINE, R. |
分类号 |
C12N15/00;A01K67/027 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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