发明名称 |
PHARMACEUTICAL FORMULATION IN MIXED MICELLAR FORM AND DISPENSER FOR ORAL DELIVERY OF AGENTS AS A SPRAY |
摘要 |
<p>A pharmaceutical formulation delivered as a spray from a metered dose dispenser into the oral cavity for absorption through oral mucosa, comprising an effective amount of (a) a pharmaceutical agent in mixed micellar form, (b) a micelle-forming compound that is an alkali metal alkyl sulfate or a polyoxyethylene sorbitan monooleate, (c) a block copolymer of polyoxyethylene and polyoxypropylene, (d) at least one additional micelle-forming compound, and (e) a suitable solven. The invention also provides a dispenser containing the present formulation, and a method of administering this formulation comprising insulin as the pharmaceutical agent, where a dose of the formulation is split to be administered before and after each meal.</p> |
申请公布号 |
WO2009015456(A1) |
申请公布日期 |
2009.02.05 |
申请号 |
WO2007CA01345 |
申请日期 |
2007.07.30 |
申请人 |
GENEREX PHARMACEUTICALS INC.;GLUSKIN, ANNA E.;QAZI, MUHAMMAD WASEEM TAHIR |
发明人 |
GLUSKIN, ANNA E.;QAZI, MUHAMMAD WASEEM TAHIR |
分类号 |
A61K38/28;A61K9/12;A61K47/20;A61K47/28;A61K47/34;A61M11/00 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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