POLYENE DIESTER ANTIBIOTICS

摘要

The present invention discloses novel polyene diesters of formula 1 and their preparation. The diesters are used as prodrugs by introducing diester group to polyene antibiotics, which exhibit antifungal or antiviral activity through releasing parent polyenes by esterase in vivo. These new derivatives have good antimicrobial activity and better safety. These new derivatives are useful for the antifungal and antiviral treatment. PA-COOR Formula 1