| 摘要 |
Disclosed herein are a method of preparing a technetium-99m-labeled iron oxide (Fe2O3) nanoparticle and a diagnostic imaging or therapeutic agent for cancer diseases comprising the nanoparticle. The 99mTc-iron oxide nanoparticle is prepared using an acidic solution or a borohydride anion exchange resin as a reducing agent, and thus, is easy to inject into the body, and its biodistribution and excretion from the body is easily predicted. The 99mTc-iron oxide nanoparticle eliminates cancerous tissues as well as enabling non-invasive real-time imaging for obtaining anatomical information about cancerous tissues and tissue functions without the need for surgery. Also, the iron oxide nanoparticle may be useful as an imaging agent for various diseases including tumors, contagious diseases and genetic defects.
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