METHODS FOR REVERTING METHYLATION BY TARGETING DNMT3A AND DNMT3B
摘要
Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed.
申请公布号
WO2009018303(A2)
申请公布日期
2009.02.05
申请号
WO2008US71532
申请日期
2008.07.30
申请人
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION;CROCE, CARLO, M.;FABBRI, MULLER