发明名称 |
SPLROPIPERIDINE COMPOUNDS, A PROCESS OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THE TREATMENT OF AIRWAY DISEASES, INFLAMMATORY DISEASES, COPD OR ASTHMA |
摘要 |
<p>The present invention relates to new polymorphs of compounds 2-{2-Chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid, and the hydrochloride and sodium hydroxide salts thereof,and compound 2-{2-Chloro-5-{[(2R)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4- [(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid. The invention further relates to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention also relates to processes for the preparation of said compounds.</p> |
申请公布号 |
WO2009011655(A1) |
申请公布日期 |
2009.01.22 |
申请号 |
WO2008SE50878 |
申请日期 |
2008.07.16 |
申请人 |
ASTRAZENECA AB;HEMMERLING, MARTIN;IVANOVA, SVETLANA;MENSONIDES-HARSEMA, MARGUERITE;SCHULZ, HAAKAN |
发明人 |
HEMMERLING, MARTIN;IVANOVA, SVETLANA;MENSONIDES-HARSEMA, MARGUERITE;SCHULZ, HAAKAN |
分类号 |
C07D491/107;A61K31/438;A61P11/00 |
主分类号 |
C07D491/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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