发明名称 |
Method of producing macrocyclic ketone, and intermediate thereof |
摘要 |
A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentration but under practical condition. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper or nickel catalyst and an enol anion scavenger to obtain a 3-methyl-1-cyclopentadecene derivative represented by General Formula (II) and then solvolyzing the enol moiety of the 3-methyl-1-cyclopentadecene derivative to obtain muscone.
|
申请公布号 |
US7479574(B2) |
申请公布日期 |
2009.01.20 |
申请号 |
US20040667476 |
申请日期 |
2004.11.11 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
MATSUDA HIROYUKI;TANAKA SHIGERU |
分类号 |
C07C45/00 |
主分类号 |
C07C45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|