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发明名称
高效、稳定且非免疫抑制之抗-CD4抗体
摘要
本发明揭示与CD4特异性结合之新颖抗体及其片段。本发明揭示抗-CD4抗体,其在铰链区中具有防止链内双硫键形成之胺基酸取代,造成具有令人惊讶之改良二价稳定性之抗体分子。增加之稳定性有利于制造,且提供增加之活体内稳定性。本发明亦揭示具有减少与Fc受体结合及ADCC活性且对CD4内化亦产生令人惊讶效应之胺基酸取代的抗体。另外,本发明揭示该等抗体之基因,该等基因已经修饰以使其具有增加之表现超过其未经修饰对应物。
申请公布号
TW200902547
申请公布日期
2009.01.16
申请号
TW097115583
申请日期
2008.04.28
申请人
建南德克公司
发明人
山加亚 辛格;麦可S C 方;黄丹阳
分类号
C07K16/18(2006.01);C07K16/28(2006.01);C07K16/42(2006.01);A61K39/395(2006.01);A61P31/18(2006.01)
主分类号
C07K16/18(2006.01)
代理机构
代理人
陈长文
主权项
地址
美国
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